If you want a quick and easy day trip from San Mateo, then drive down the coast of California via US Highway 1.
You can easily reach this picturesque route just minutes from the center of the city as it is the main highway to and from San Francisco.
San Mateo, California to US 1 is an easy drive and you can stop along the road to look out at the Pacific at various vistas. US 1 trips from San Mateo will take you through the heart of California all the way to L.A. Of course, you do not need to go all the way to enjoy the natural beauty surrounding this road.
You can make a stop near Hollister, CA where you will find fruit stands full of fresh and plump melons and strawberries.
You can even make a reservation at the famous Madonna Inn that is located halfway between San Francisco and L.A. Each room is a made of a different theme and a great destination for a quick getaway from San Mateo.